Tylenol Avoid or Not to Avoid? Acetaminophen (Tylenol) can deplete glutathione, your body's most important detox antioxidant. This matters even more if your child has an MTHFR gene mutation, which Is Tylenol Safe During Pregnancy? Risk Factors, Not Causation History of Tylenol: Acetaminophen and Its Origins TikTok Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect Just say NO to Tylenol