Acetaminophen or Tylenol Toxicity Lect 19 Pharmacology Acetaminophen and aspirin toxicity are both high yield, but the injury pattern is very different. Acetaminophen overdose overwhelms glutathione, allowing NAPQI to build up and cause hepatic necrosis. The antidote is N acetylcysteine, which View of Acetaminophen, the missing anion gap in the patient with metabolic acidosis The Southwest journal of medicine Acetaminophen toxicity EMCrit Project Silymarin prevents acetaminophen induced hepatotoxicity via up regulation of the glutathione conjugation capacity in mice ScienceDirect