Ibuprofen administration attenuates serum TNF levels, hepatic glutathione depletion, hepatic apoptosis and mouse mortality after Fas stimulation ScienceDirect Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Glutathione Benefits, Safety & Myths Explained The Dos and Donts for Having Beautiful Glowing Skin NEOS Med Spa Condensed structural chemical formula of glutathione (IUPAC name: Download Scientific Diagram