Sensitized mast cells for targeted drug delivery and augmented cancer immunotherapy: Cell Frontiers Ironing out COPD: ferroptosis driven immune dysregulation, metabolic rewiring, and precision therapeutic opportunities Mast Cell Activation Syndrome and Its Impact on the Lymphatics Glutathione: Master Antioxidant, Reducing Oxidative Stress, and Detoxification Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione.