TOXICOLOGY PARACETAMOL POISONING Alcohol and paracetamol are both processed through the liver. Paracetamol can form a toxic metabolite called NAPQI, which the body usually neutralises safely. But factors like heavy alcohol use, repeated dosing, fasting, Tox and Hound Fellow Friday What Terror Hath NAPQI Wrought? TYLENOL [Aetaminophen] metabolism Cyp 3A4 and 2E1: CYP3A4 is the major Cytochrome P 450 [Cyp] enzyme that catalyzes acetaminophen oxidation into NAPQI in human Phase I liver detox. The other Cyp enzyme Acetaminophen metabolism explained "simply" Since it's been blowing up my feed this week (this is not considering metabolic fates changes when pregnant) Your liver normally clears acetaminophen (Apap) safely, but in overdose, its
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napqi glutathione Problem 2: N-acetyl para-benzoquinone (NAPQI) is an oxidized metabolite of acetaminophen formed in the liver. NAPQI is converted into an acetaminophen-glutathione conjugate, a non-toxic metabolite