Mast cells are hypersensitive immune cells that release histamine and other inflammatory mediatorsoften in response to oxidative stress, environmental toxins, and immune imbalance. Many patients with MCAS have low levels of glutathione. Most women I talk to with histamine issues are stuck in a cycle: Remove more foods feel a little better react again remove even more And it becomes exhausting. Immunocytochemical Localization of Amines and GABA in the Optic Lobe of the Butterfly, Papilio xuthus PLOS One Novel insights on the biology and immunologic effects of histamine: A road map for allergists and mast cell biologists ScienceDirect Glutathione Benefits for Your Health and Body