Department of Genetic Engineering @ SRM University: Genetic Awareness Program on Glucose 6 Phosphate Dehydrogenase Deficiency Treatment strategies for glucose 6 phosphate dehydrogenase deficiency: past and future perspectives: Trends in Pharmacological Sciences Anemia (Chapter 3) Pediatric Pathology of Hematopoietic and Histiocytic Disorders G6PD Deficiency Causes Haemolytic Anaemia Glucose 6 phosphate dehydrogenase is an enzyme in the hexose monophosphate shunt that synthesizes NADPH. The NADPH is used to convert oxidized glutathione (GSSG) to reduced glutathione ( In RBCs, NADPH are produced exclusively via HMP shunt by the action of G6PD and are responsible to maintain membrane integrity preventing premature destruction. That is why G6PD deficient RBCs are