An Example of a Drug That Causes Toxicity Through the Formation of a Chemically Reactive Intermediate Mechanisms of Adverse Drug Reactions Pharmacovigilance Full article: Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem Sex differences in glutathione metabolism and acetaminophen toxicity Paracetamol overdose British Journal of Hospital Medicine