Glutathione: The Master Antioxidant Core Med Science Did you know one single mast cell can release chemicals that affect your skin, gut, heart, brain, and immune system all at once? That's why MCAS can feel so overwhelming, the Glutathione is a critical soldier in our line of defense. We even have mechanisms that recycle and reuse it. But what happens when our toxic burden becomes too high? Our genetic detoxification Identification of cytotoxic, glutathione reactive moieties inducing accumulation of reactive oxygen species via glutathione depletion ScienceDirect Glutathione prevents high glucose induced pancreatic fibrosis by suppressing pancreatic stellate cell activation via the ROS TGF SMAD pathway Cell Death & Disease