Labial Macules: Dark Spots on the Lip Dermatology Advisor Treatment of labial melanotic macules on the lip. These are benign spots that appear on the lips for no apparent reason. The causes are mostly genetic, but similar spots can appear in smokers, after Melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight in single basal melanocytes; NO nests. More info like this in Mucosal melanocytic macules Oral pathology: Noting a pigmented macule that often presents a diagnostic dilemma Registered Dental Hygienists
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