Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells Cell Death & Disease Initial Glutathione Depletion During Short Term Bed Rest: Pinpointing Synthesis and Degradation Checkpoints in the Glutamyl Cycle Glutathione and Autoimmune Disease Master Antioxidant Do You Have a Glutathione Deficiency?