Methylation cycle hypothesis MEpedia Your blood tests are normal. Your sleep is adequate. You're still exhausted. This is the most common presentation I see in clinic and the answer is almost never found on a Histone modificationdriven structural remodeling unleashes DNMT3B in DNA methylation Science Advances Do you suffer with fatigue, brain fog, mood swings, or trouble detoxing? These could be signs of an MTHFR gene mutation, which affects methylationa key process for energy, detoxification, brain function, and HOTAIR interacts with PRC2 complex regulating the regional preadipocyte transcriptome and human fat distribution: Cell Reports