Acetaminophen's Role in Autism and ADHD: A Mitochondrial Perspective Your livers unsung hero: Glutathione , Lets talk about what really happens when you take Tylenol (acetaminophen)., Your liver breaks down acetaminophen through several pathways. One pathway creates Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Assessment of the biochemical pathways for acetaminophen toxicity: Implications for its carcinogenic hazard potential ScienceDirect The role of oxidative stress, inflammation and acetaminophen exposure from birth to early childhood in the induction of autism