Problem 2: N acetyl para benzoquinone (NAPQI) is an oxidized Acetaminophen and Codeine Phosphate Tablets, USP CIII 3 Glutathione Rescue Normally, glutathione binds NAPQI and converts it into non toxic byproducts (cysteine + mercapturic acid) that are excreted. Example: Glutathione is your liver's safety net against toxins. Metabolism of acetaminophen (paracetamol) in plantstwo independent pathways result in the formation of a glutathione and a glucose conjugate Environmental Science and Pollution Research Springer Nature Link Sex differences in glutathione metabolism and acetaminophen toxicity