Glutathione, Tylenol & Your Health: What You Should Know Mechanisms of acetaminophen induced liver injury and its implications for therapeutic interventions ScienceDirect Amazon.com: Tylenol Proactive Support from, Muscle and Joint Supplements for Women and Men, Drug Free, Tamarind, Turmeric, Cucumber Extract to Improve Joint Comfort and Flexibility, 30Count, 1Month Supply Tylenol's Impact on Glutathione and Liver Damage Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.