5 Oxoprolinuria as a Cause for Metabolic Acidosis Renal Fellow Network Paracetamol (acetaminophen) toxicity occurs when the liver is overwhelmed by a toxic metabolite called N acetyl p benzoquinone imine (NAPQI), which is normally detoxified by glutathione. In overdose, glutathione is depleted, and NAPQI accumulates, leading Acute acetaminophen paracetamol toxicity Maternal Biomarkers of Acetaminophen Use and Offspring Attention Deficit Hyperactivity Disorder 3 (glutathion S yl)acetaminophen C18H24N4O8S CID 83998 PubChem