Mold Illness is More Than a Chronic Inflammatory Response Syndrome Dr. Todd Maderis Identification of cytotoxic, glutathione reactive moieties inducing accumulation of reactive oxygen species via glutathione depletion ScienceDirect Deficient Glutathione in the Pathophysiology of Mycotoxin Related Illness Mold mycotoxins deplete the body of its master antioxidant glutathione. In true Tolkien homage, I refer to glutathione as 'the one antioxidant to rule them all. It's a critical detoxifier of Mycotoxins are toxic. But they are only one of many stressors affecting the extracellular matrix. Ochratoxin, aflatoxins, and trichothecenes increase oxidative stress, deplete glutathione, disrupt mitochondria, and activate inflammatory signaling. That