Dihexa (also known as PNB 0408) is an experimental small molecule derived from angiotensin IV. It was engineered to cross the bloodbrain barrier and has shown synaptogenic effects in preclinical models. The often quoted Mechanistically detailed systems biology modeling of the HGF Met pathway in hepatocellular carcinoma npj Systems Biology and Applications Structural basis of the activation of c MET receptor Nature Communications Small molecule activation of the neurotrophin hepatocyte growth factor to treat Alzheimer disease HGF c Met pathway facilitates the perineural invasion of pancreatic cancer by activating the mTOR NGF axis Cell Death & Disease