Paracetamol (acetaminophen) toxicity occurs when the liver is overwhelmed by a toxic metabolite called N acetyl p benzoquinone imine (NAPQI), which is normally detoxified by glutathione. In overdose, glutathione is depleted, and NAPQI accumulates, leading Acetaminophen, a Therapeutic or an Extremely Toxic RemedyA Review The molecular mechanisms of acetaminophen induced hepatotoxicity and its potential therapeutic targets Guangwen Luo, Lili Huang, Zhaowei Zhang, 2023 Solved The following figure shows the metabolism of the Chegg.com Acetaminophen Pathway (toxic doses), Pharmacokinetics