(REAL TEST) Can Smoke Detectors Detect Vape? (compared with a Vape Detector) Hotel Vape and Smoke Detector Halo Smart Sensor Does anyone know if Vape smoke will set off this hotel fire alarm? : r Vaping Can a Vape Set Off a Fire Alarm? What You Should Know Your guests aren't the only ones checking in. So are their vape pens. With over 13 million regular vapers in the U.S. alone, unauthorized vaping is a major operational risk for hotels.