A 48 hour fast can turn standard Paracetamol into acute liver failure. Fasting depletes Glutathione, leaving the liver defenseless against toxic NAPQI. Review the latest guidelines on BMJ Best Practice: https: bestpractice.bmj.com topics en us 1010 Frontiers Paracetamol Induced Glutathione Consumption: Is There a Link With Severe COVID 19 Illness? The biochemistry of acetaminophen hepatotoxicity and rescue: a mathematical model Theoretical Biology and Medical Modelling Springer Nature Link NAPQI Wikipedia Paracetamol is one of the most commonly used analgesic and antipyretic drugs.
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